The bacteriologist and virologist Thomas Milton Rivers spent over thirty years at the Rockefeller Institute as a researcher in the Department of Bacteriology and from 1937-1955, as Director. Working on measles and pneumonia, Rivers discovered the parainfluenzae bacillus and cultivated vaccine virus for human use, and during the 1950s, he played an important role in coordinating research on poliomyelitis as head of the National Institute for Infantile Paralysis. During the Second World War, Rivers led the Naval Medical Research Unit in the South Pacific, rising to the rank of Rear Admiral. The Rivers Papers contains correspondence, laboratory notes, speeches, and photographs documenting Rivers' activities at the Rockefeller Institute, the development of polio vaccine, and Rivers' Navy experience in the Pacific during World War II.

A physician and naturalist, Oswald Hope Robertson worked at the Rockefeller Institute, the Peking Union Medical College, and at the medical school of University of Chicago (1927-1951). With a broad range of research interests, Robertson contributed important work on the transmission of pneumonia, the disinfection of air with glycol vapors, and later in his career, on the physiology and ecology of salmonid fishes. He is best remembered, however, as the creator of the first blood bank, established for use by British and American forces during the First World War. The Robertson Papers contain correspondence, notes, articles, and notebooks on many of Robertson's major research interests, including his work on blood. His early work on salmonid ecology is represented in a journal and eleven notebooks stemming from fieldwork in the lakes of the Wind River Range in northwestern Wyoming, 1942-1951. There is also interesting material on the Research Corporation (New York City) concerning patents on glycol vapors and air sterilizers, as well as notes and manuscripts of papers on morphine experiments, canine pneumococcus, bacteremia, and the effects of hydrocortisone.

A pathologist and researcher at the Rockefeller Institute of Medical Research, 1914-1922, Harold Lindsay Amoss (1886-1956) specialized in research on infectious diseases ranging from poliomyelitis to meningitis, erysipelas, brucellosis, and encephalitis. The Amoss Papers are comprised primarily of materials relating to Harold Amoss' medical service in the United States Army during the First World War (1918-1919), to his research at the Rockefeller Institute of Medical Research, 1920-1922, and to his efforts to develop vaccines for meningitis and poliomyelitis.

Simon Flexner, born in 1863, one of the nation's leading experts in pathology and bacteriology, was most renowned for his research on cerebrospinal meningitis, polio and infantile paralysis. Arguably though, Flexner's stewardship of the Rockefeller Institute was his greatest contribution to medical and scientific research. His rise in the medical community began in the late nineteenth century in Louisville, Kentucky, where despite not having completed even the seventh grade, Flexner taught himself basic bacteriology by conducting experiments at home using a microscope borrowed from the pharmacy where he served as an apprentice. Granted a medical degree from the University of Louisville School of Medicine in 1889, he went on to a pathology fellowship at the newly opened John Hopkins School of Medicine. Within two short years of leaving Louisville, Flexner received an assistant of pathology appointment at Johns Hopkins. It was a quick ascent and the beginning of a long and brilliant career that included a prestigious appointment at the University of Pennsylvania and then a directorship at the new Rockefeller Institute where he realized his lifelong dream of creating a dynamic and productive research laboratory. The Rockefeller Institute became instantly famous worldwide as the preeminent research facility for virology and under Flexner's direction produced invaluable contributions in pathology, bacteriology, and immunology. This collection does not reflect the early phases of Flexner's career at Johns Hopkins but does document an early interest in meningitis and other infectious diseases with science-related correspondence, laboratory notebooks, and administrative correspondence with the New York City and State Departments of Health. There is abundant material on Flexner's directorship of the Rockefeller Institute for Medical Research, including Flexner's search for staff, an involved process which is detailed in correspondence with the scientists, many of whom became quite famous. Also included is material relating to the other institutions and Rockefeller philanthropies with which Flexner was involved. (Among the most significant correspondence, however, may be that which documents the support of the General Education Board and the Rockefeller Foundation in the development and subsequent reorganization of medical schools following brother Abraham Flexner's scathing report on medical education in the United States and Canada). This collection would be of great interest to anyone interested in the history of bacteriology, histology, and immunology or the general history of modern medicine and philanthropy.

Correspondence, notebooks, research data related to Cole's career as the first director at the Hospital of the Rockefeller Institute of Medical Research, 1908-1937. His research of pneumonia was conducted when the disease was epidemic. Personal correspondence reflect Cole's life as a medical resident at Johns Hopkins, 1899-1908. Documented are his memberships in leading medical organizations throughout his career, including the Association of American Physicians and the New York Academy of Medicine. This collection showcases the evolving changes in the medical profession from practicing physician to clinician.